Understanding the lipid nanoparticles structure dynamics using a time-resolved saxs measurement

Masatoshi Maeki, Niko Kimura, Kazuki Shimizu, Kento Yonezawa, Nobutaka Shimizu, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

This paper reports a time-resolved small angle X-ray scattering (SAXS) for understanding lipid nanoparticles (LNPs) structure dynamics. The structure and its dynamics are the indispensable factors to ensure the activity and therapeutic effect of LNP-based nanomedicines. However, the structure dynamics of LNPs are not well understood because of the limitation of measurement methodology. To overcome the problem, we developed microfluidic-based SAXS measurement technique combined with a synchrotron X-ray source. We confirmed the LNPs decomposition process and LNPs aggregation process by pH change of the solution.

本文言語英語
ホスト出版物のタイトル23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
出版社Chemical and Biological Microsystems Society
ページ1478-1479
ページ数2
ISBN(電子版)9781733419000
出版ステータス出版済み - 2019
外部発表はい
イベント23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, スイス
継続期間: 10月 27 201910月 31 2019

出版物シリーズ

名前23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

会議

会議23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
国/地域スイス
CityBasel
Period10/27/1910/31/19

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 化学工学(その他)

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