Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?

Jun Ichi Kira

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)

抄録

Some disease-modifying drugs for multiple sclerosis, which mainly act on T cells, are ineffective for neuromyelitis optica spectrum disorder and induce unexpected relapses. These include interferon beta, glatiramer acetate, fingolimod, natalizumab, and alemtuzumab. The cases reported here suggest that dimethyl fumarate, which reduces the number of Th1 and Th17 cells and induces IL-4-producing Th2 cells, is also unsuitable for neuromyelitis optica spectrum disorder, irrespective of anti-aquaporin 4 IgG serostatus. Although oral dimethyl fumarate with manageable adverse effects is easy to initiate in the early course of multiple sclerosis, special attention should be paid for atypical demyelinating cases.

本文言語英語
ページ(範囲)1300-1302
ページ数3
ジャーナルMultiple Sclerosis
23
9
DOI
出版ステータス出版済み - 8月 1 2017

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

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