Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?

Jun Ichi Kira

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

Some disease-modifying drugs for multiple sclerosis, which mainly act on T cells, are ineffective for neuromyelitis optica spectrum disorder and induce unexpected relapses. These include interferon beta, glatiramer acetate, fingolimod, natalizumab, and alemtuzumab. The cases reported here suggest that dimethyl fumarate, which reduces the number of Th1 and Th17 cells and induces IL-4-producing Th2 cells, is also unsuitable for neuromyelitis optica spectrum disorder, irrespective of anti-aquaporin 4 IgG serostatus. Although oral dimethyl fumarate with manageable adverse effects is easy to initiate in the early course of multiple sclerosis, special attention should be paid for atypical demyelinating cases.

本文言語英語
ページ(範囲)1300-1302
ページ数3
ジャーナルMultiple Sclerosis
23
9
DOI
出版ステータス出版済み - 8 1 2017

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

フィンガープリント 「Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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