Unified synthesis of the DEF and GhI ring systems of maitotoxin

Takaya Yasudomi, Hiroyuki Yakushiji, Kohei Torikai, Makoto Ebine, Tohru Oishi

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Unified synthesis of 6/6/6-tricyclic ethers corresponding to the DEF and GHI ring systems of maitotoxin was achieved from a common intermediate prepared from a furan derivative and a terminal olefin via FujiwaraMoritani reaction, followed by Sharpless asymmetric dihydroxylation, and Achmatowicz reaction. The DEF ring was synthesized from the common intermediate via regio- and stereoselective borylation of an enone, and methylation of an S, O-acetal. On the other hand, the GHI ring was synthesized from the common intermediate via reductive etherification, Sharpless asymmetric dihydroxylation, and BartonMcCombie deoxygenation.

本文言語英語
ページ(範囲)1156-1159
ページ数4
ジャーナルChemistry Letters
48
9
DOI
出版ステータス出版済み - 2019

All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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