Unified Total Synthesis of Pentacyclic Stemoamide-type Alkaloids

Yasuki Soda, Yasukazu Sugiyama, Makoto Yoritate, Hayato Tajima, Kana Shibuya, Chisato Ogihara, Takeshi Oishi, Takaaki Sato, Noritaka Chida

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

The collective synthesis of pentacyclic stemoamide-type alkaloids is recognized as a daunting task despite high demand for a comprehensive biological profiling of these natural products. In this Letter, we report a unified synthesis of seven pentacyclic alkaloids and two unnatural derivatives. The keys to success are (1) the chemoselective assembly of four five-membered building blocks, (2) the direct oxidation of pyrrolidine natural products to pyrrole derivatives, and (3) the stereodivergent construction of totally E- or Z-substituted butenolides.

本文言語英語
ページ(範囲)7502-7507
ページ数6
ジャーナルOrganic letters
22
19
DOI
出版ステータス出版済み - 10 2 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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