Unifying framework for rule semantics: Application to gene expression data

Marie Agier, Jean Marc Petit, Einoshin Suzuki

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

The notion of rules is very popular and appears in different flavors, for example as association rules in data mining or as functional dependencies in databases. Their syntax is the same but their semantics widely differs. In the context of gene expression data mining, we introduce three typical examples of rule semantics and for each one, we point out that Armstrong's axioms are sound and complete. In this setting, we propose a unifying framework in which any "well-formed" semantics for rules may be integrated. We do not focus on the underlying data mining problems posed by the discovery of rules, rather we prefer to discuss the expressiveness of our contribution in a particular application domain: the understanding of gene regulatory networks from gene expression data. The key idea is that biologists have the opportunity to choose - among some predefined semantics - or to define the meaning of their rules which best fits into their requirements. Our proposition has been implemented and integrated into an existing open-source system named MeV of the TIGR environment devoted to microarray data interpretation. An application has been performed on expression profiles of a sub-sample of genes from breast cancer tumors.

本文言語英語
ページ(範囲)543-559
ページ数17
ジャーナルFundamenta Informaticae
78
4
出版ステータス出版済み - 9 18 2007

All Science Journal Classification (ASJC) codes

  • 理論的コンピュータサイエンス
  • 代数と数論
  • 情報システム
  • 計算理論と計算数学

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