Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection

Manabu Nakazono, Konen Obayashi, Yuji Oshikawa, Kazushi Tani, Genki Suenaga, Yukio Ando, Shinkoh Nanbu, Ryoichi Kuwano

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

Various unsymmetric indolylmaleimides were synthesized. Their photophysical properties and affinities for amyloid fibrils were evaluated. Some unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. From the results of histopathologic methods using stains, 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione has high selectivity for amyloid fibrils in senile systemic amyloidosis.

本文言語英語
ページ(範囲)39-46
ページ数8
ジャーナルJournal of Photochemistry and Photobiology A: Chemistry
289
DOI
出版ステータス出版済み - 9 1 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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