TY - JOUR
T1 - Upregulation of cytochrome p450s following exposure of the silkmoth, Bombyx mori to insecticides
AU - Yamamoto, Kohji
AU - Ichinose, Hirofumi
AU - Aso, Yoichi
AU - Udono, Miyako
AU - Katakura, Yoshinori
PY - 2013/12/12
Y1 - 2013/12/12
N2 - We examined which proteins were enhanced in the silkmoth in response to its exposure to insecticides. We previously found that the levels of four cytochrome P450s (CYPs) were higher following insecticide exposure (Yamamoto et al., 2010). In this study, we focused on other mRNAs encoding the silkmoth CYP proteins (CYP6B29, CYP18A1, CYP366A1, CYP302A1) induced. mRNA expression analysis revealed that each CYP mRNA was expressed in a tissue-specifc manner and that expression was developmentally regulated. Quantitative PCR revealed that these CYP mRNAs were upregulated in the larval fat body after exposure of the silkmoth to various insecticides. Our results suggest that the CYPs can contribute to insecticide resistance in Lepidopterans.
AB - We examined which proteins were enhanced in the silkmoth in response to its exposure to insecticides. We previously found that the levels of four cytochrome P450s (CYPs) were higher following insecticide exposure (Yamamoto et al., 2010). In this study, we focused on other mRNAs encoding the silkmoth CYP proteins (CYP6B29, CYP18A1, CYP366A1, CYP302A1) induced. mRNA expression analysis revealed that each CYP mRNA was expressed in a tissue-specifc manner and that expression was developmentally regulated. Quantitative PCR revealed that these CYP mRNAs were upregulated in the larval fat body after exposure of the silkmoth to various insecticides. Our results suggest that the CYPs can contribute to insecticide resistance in Lepidopterans.
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U2 - 10.11416/jibs.82.2_033
DO - 10.11416/jibs.82.2_033
M3 - Article
AN - SCOPUS:84889688168
VL - 82
SP - 33
EP - 38
JO - Journal of Insect Biotechnology and Sericology
JF - Journal of Insect Biotechnology and Sericology
SN - 1346-8073
IS - 2
ER -