Urticaria type drug eruption that occurred three days after completion of oral administration of minocycline hydrochloric acid

On the third day after completion of 15-day oral administration of minocycline hydrochloric acid (Minomycin®), edematous erythema over the entire body accompanying breathing difficulty developed in a 39-year-old woman. She was admitted to hospital and treatment with prednisolone (Prednine®) at 40 mg/day was started. A diagnosis of urticaria type drug eruption caused by minocycline hydrochloric acid was made on the basis of results of pathological histology and reoral tests. To the best of our knowledge, there has been no report on urticaria type drug eruption 3 days after oral administration of minocycline hydrochloric acid. It was thought that characteristic pharmacokinetics of minocycline hydrochloric acid were involved.