Use of heavy drinking donors in heart transplantation is not associated with worse mortality

Sharven Taghavi, Senthil N. Jayarajan, Eugene Komaroff, Akira Shiose, Daniel Schwartz, Eman Hamad, Rene Alvarez, Grayson Wheatley, T. Sloane Guy, Yoshiya Toyoda

研究成果: Contribution to journalArticle

4 被引用数 (Scopus)

抄録

Background. Although orthotopic heart transplantation (OHT) remains the preferred treatment for end-stage heart failure, there continues to be a critical shortage of organ donors. The goal of this study is to examine outcomes after orthotopic OHT using heavy drinking donors (HDDs) in a large, national database. Methods. The United Network for Organ Sharing database was examined for all primary, adult OHT carried out from 2005 to 2012. Results. There were 14,928 total OHT performed during the study period with 2,274 (15.2%) using HDD. Recipients of HDD were older (53.4 vs. 51.9 years, P < 0.001), more likely men (80.7 vs 74.4%, P < 0.001), less likely sex mismatched (21.5 vs 27.5%, P < 0.001), more likely race mismatched (57.4 vs 52.4%, P < 0.001), and had less total HLA mismatches (4.55 vs 4.65, P < 0.001). The HDD were older (37.0 vs 30.5 years, P < 0.001), more likely men (82.2 vs 69.9%, P < 0.001), and more likely to have heavy cigarette use (38.1 vs 13.2%, P < 0.001). Length of stay was not different (20.3 vs 19.7 days, P = 0.02). On multivariate analysis, use of HDD was not associated with mortality at 30 days (hazards ratio [HR], 1.12; 95% confidence interval [95% CI], 0.90-1.39; P = 0.30), 1 year (HR, 0.96; 95% CI, 0.83-1.11; P = 0.56), and at 5 years (HR, 1.02; 95% CI, 0.91-1.13; P = 0.79). Variables associated with mortality at 5 years included increasing donor age, prolonged ischemic time, worsening recipient creatinine, recipient black race, sex mismatch, and extracorporeal membrane oxygenation or mechanical ventilation as a bridge to transplantation. Conclusion. Heart transplantation can be performed using carefully selected HDDs with good outcomes.

本文言語英語
ページ(範囲)1226-1230
ページ数5
ジャーナルTransplantation
99
6
DOI
出版ステータス出版済み - 6 6 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • Transplantation

フィンガープリント 「Use of heavy drinking donors in heart transplantation is not associated with worse mortality」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル