Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor

Wataru Hatanaka, Miki Kawaguchi, Xizheng Sun, Yusuke Nagao, Hiroyuki Ohshima, Mitsuru Hashida, Yuriko Higuchi, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

We developed a strategy to modify cell membranes with an artificial transmembrane receptor. Coulomb force on the receptor, caused by the membrane potential, was used to achieve membrane penetration. A hydrophobically modified cationic peptide was used as a membrane potential sensitive region that was connected to biotin through a transmembrane oligoethylene glycol (OEG) chain. This artificial receptor gradually disappeared from the cell membrane via penetration despite the presence of a hydrophilic OEG chain. However, when the receptor was bound to streptavidin (SA), it remained on the cell membrane because of the large and hydrophilic nature of SA.

元の言語英語
ページ(範囲)296-301
ページ数6
ジャーナルBioconjugate Chemistry
28
発行部数2
DOI
出版物ステータス出版済み - 2 15 2017

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Artificial Receptors
Cell membranes
Membrane Potentials
Glycols
Streptavidin
Cell Membrane
Membranes
Biotin
Peptides

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

これを引用

Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor. / Hatanaka, Wataru; Kawaguchi, Miki; Sun, Xizheng; Nagao, Yusuke; Ohshima, Hiroyuki; Hashida, Mitsuru; Higuchi, Yuriko; Kishimura, Akihiro; Katayama, Yoshiki; Mori, Takeshi.

:: Bioconjugate Chemistry, 巻 28, 番号 2, 15.02.2017, p. 296-301.

研究成果: ジャーナルへの寄稿記事

Hatanaka, Wataru ; Kawaguchi, Miki ; Sun, Xizheng ; Nagao, Yusuke ; Ohshima, Hiroyuki ; Hashida, Mitsuru ; Higuchi, Yuriko ; Kishimura, Akihiro ; Katayama, Yoshiki ; Mori, Takeshi. / Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor. :: Bioconjugate Chemistry. 2017 ; 巻 28, 番号 2. pp. 296-301.
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AU - Ohshima, Hiroyuki

AU - Hashida, Mitsuru

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AU - Kishimura, Akihiro

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AU - Mori, Takeshi

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