Use of synthetic peptides for non-viral gene delivery

Takuro Niidome, Yoshiki Katayama

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

抄録

The development of non-viral gene delivery systems is an important key to solving several problems occurring in viral gene delivery, such as endogenous virus recombination, oncogenic effects and unexpected immune responses.As discussed in other chapters of this book, most of the basic techniques of non-viral gene delivery systems have relied on liposome and polymer chemistries; however, peptide chemistry has also contributed strongly to this field. Peptides can be synthesized automatically or manually and their chemistry allows the design and synthesis of complicated structures, e.g. ligand-modified peptides recognizable by specific cells, dye-modified peptides to trace their locations in cells and tissues, and other "intelligent" peptides to achieve functional gene delivery. It is expected that the relative ease of peptide construction will provide researchers with a wide range of molecules as well as important information about the structural requirements for functional gene delivery. Peptides play many roles in gene delivery, such as providing a simple cationic moiety to bind DNA, acting as a ligand or facilitating the release of DNA into the cytosol, carrying a signal for transport to the nucleus, or functioning as a sensor for the regulation of gene expression in cells. In this chapter, some examples of the use of peptides in gene delivery are described, and the prospects of utilizing such peptides in gene therapy are discussed.

元の言語英語
ホスト出版物のタイトルNon-viral Gene Therapy
ホスト出版物のサブタイトルGene Design and Delivery
出版者Springer-Verlag Tokyo
ページ87-102
ページ数16
ISBN(電子版)9784431278795
ISBN(印刷物)4431251227, 9784431251224
DOI
出版物ステータス出版済み - 1 1 2005

Fingerprint

Genes
Peptides
Gene Transfer Techniques
Ligands
Gene therapy
Oncogenic Viruses
Viral Genes
DNA
Gene Expression Regulation
Viruses
Gene expression
Liposomes
Genetic Therapy
Cytosol
Genetic Recombination
Polymers
Coloring Agents
Research Personnel
Tissue
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Niidome, T., & Katayama, Y. (2005). Use of synthetic peptides for non-viral gene delivery. : Non-viral Gene Therapy: Gene Design and Delivery (pp. 87-102). Springer-Verlag Tokyo. https://doi.org/10.1007/4-431-27879-6_8

Use of synthetic peptides for non-viral gene delivery. / Niidome, Takuro; Katayama, Yoshiki.

Non-viral Gene Therapy: Gene Design and Delivery. Springer-Verlag Tokyo, 2005. p. 87-102.

研究成果: 著書/レポートタイプへの貢献

Niidome, T & Katayama, Y 2005, Use of synthetic peptides for non-viral gene delivery. : Non-viral Gene Therapy: Gene Design and Delivery. Springer-Verlag Tokyo, pp. 87-102. https://doi.org/10.1007/4-431-27879-6_8
Niidome T, Katayama Y. Use of synthetic peptides for non-viral gene delivery. : Non-viral Gene Therapy: Gene Design and Delivery. Springer-Verlag Tokyo. 2005. p. 87-102 https://doi.org/10.1007/4-431-27879-6_8
Niidome, Takuro ; Katayama, Yoshiki. / Use of synthetic peptides for non-viral gene delivery. Non-viral Gene Therapy: Gene Design and Delivery. Springer-Verlag Tokyo, 2005. pp. 87-102
@inbook{47b2676141df46fdbbbe39353fc6d0f2,
title = "Use of synthetic peptides for non-viral gene delivery",
abstract = "The development of non-viral gene delivery systems is an important key to solving several problems occurring in viral gene delivery, such as endogenous virus recombination, oncogenic effects and unexpected immune responses.As discussed in other chapters of this book, most of the basic techniques of non-viral gene delivery systems have relied on liposome and polymer chemistries; however, peptide chemistry has also contributed strongly to this field. Peptides can be synthesized automatically or manually and their chemistry allows the design and synthesis of complicated structures, e.g. ligand-modified peptides recognizable by specific cells, dye-modified peptides to trace their locations in cells and tissues, and other {"}intelligent{"} peptides to achieve functional gene delivery. It is expected that the relative ease of peptide construction will provide researchers with a wide range of molecules as well as important information about the structural requirements for functional gene delivery. Peptides play many roles in gene delivery, such as providing a simple cationic moiety to bind DNA, acting as a ligand or facilitating the release of DNA into the cytosol, carrying a signal for transport to the nucleus, or functioning as a sensor for the regulation of gene expression in cells. In this chapter, some examples of the use of peptides in gene delivery are described, and the prospects of utilizing such peptides in gene therapy are discussed.",
author = "Takuro Niidome and Yoshiki Katayama",
year = "2005",
month = "1",
day = "1",
doi = "10.1007/4-431-27879-6_8",
language = "English",
isbn = "4431251227",
pages = "87--102",
booktitle = "Non-viral Gene Therapy",
publisher = "Springer-Verlag Tokyo",

}

TY - CHAP

T1 - Use of synthetic peptides for non-viral gene delivery

AU - Niidome, Takuro

AU - Katayama, Yoshiki

PY - 2005/1/1

Y1 - 2005/1/1

N2 - The development of non-viral gene delivery systems is an important key to solving several problems occurring in viral gene delivery, such as endogenous virus recombination, oncogenic effects and unexpected immune responses.As discussed in other chapters of this book, most of the basic techniques of non-viral gene delivery systems have relied on liposome and polymer chemistries; however, peptide chemistry has also contributed strongly to this field. Peptides can be synthesized automatically or manually and their chemistry allows the design and synthesis of complicated structures, e.g. ligand-modified peptides recognizable by specific cells, dye-modified peptides to trace their locations in cells and tissues, and other "intelligent" peptides to achieve functional gene delivery. It is expected that the relative ease of peptide construction will provide researchers with a wide range of molecules as well as important information about the structural requirements for functional gene delivery. Peptides play many roles in gene delivery, such as providing a simple cationic moiety to bind DNA, acting as a ligand or facilitating the release of DNA into the cytosol, carrying a signal for transport to the nucleus, or functioning as a sensor for the regulation of gene expression in cells. In this chapter, some examples of the use of peptides in gene delivery are described, and the prospects of utilizing such peptides in gene therapy are discussed.

AB - The development of non-viral gene delivery systems is an important key to solving several problems occurring in viral gene delivery, such as endogenous virus recombination, oncogenic effects and unexpected immune responses.As discussed in other chapters of this book, most of the basic techniques of non-viral gene delivery systems have relied on liposome and polymer chemistries; however, peptide chemistry has also contributed strongly to this field. Peptides can be synthesized automatically or manually and their chemistry allows the design and synthesis of complicated structures, e.g. ligand-modified peptides recognizable by specific cells, dye-modified peptides to trace their locations in cells and tissues, and other "intelligent" peptides to achieve functional gene delivery. It is expected that the relative ease of peptide construction will provide researchers with a wide range of molecules as well as important information about the structural requirements for functional gene delivery. Peptides play many roles in gene delivery, such as providing a simple cationic moiety to bind DNA, acting as a ligand or facilitating the release of DNA into the cytosol, carrying a signal for transport to the nucleus, or functioning as a sensor for the regulation of gene expression in cells. In this chapter, some examples of the use of peptides in gene delivery are described, and the prospects of utilizing such peptides in gene therapy are discussed.

UR - http://www.scopus.com/inward/record.url?scp=84920091708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920091708&partnerID=8YFLogxK

U2 - 10.1007/4-431-27879-6_8

DO - 10.1007/4-431-27879-6_8

M3 - Chapter

AN - SCOPUS:84920091708

SN - 4431251227

SN - 9784431251224

SP - 87

EP - 102

BT - Non-viral Gene Therapy

PB - Springer-Verlag Tokyo

ER -