Usefullness of low-priming-volume cardiopulmonary bypass circuits and dilutional ultrafiltration in neonatal open-heart surgery

Fumio Fukumura, Hideaki Kado, Yutaka Imoto, Yuichi Shiokawa, Kazu Minami, Jun Murakami, Hisataka Yasui

研究成果: Contribution to journalArticle

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In neonate open-heart surgery, cardiopulmonary bypass (CPB) with extreme hemodilution induces an increased capillary permeability and accumulation of extravascular fluid, resulting in organ dysfunction. We evaluated the effects of a reduced priming volume for CPB and dilutional ultrafiltration (DUF) during neonatal open-heart surgery. Nineteen consecutive neonates with complete transposition of the great arteries who underwent an arterial switch operation were retrospectively assigned into two groups: the high-priming-volume circuit group (group A, n = 9) and the low-priming-volume circuit group (group B, n = 10). Patients in group B underwent surgery with a miniaturized CPB circuit and using the DUF technique. The priming volume of group B was nearly two-thirds that of group A. The water balance value after CPB and surgery was significantly lower in group B (-126 ± 118 ml, -116 ± 116 ml) than in group A (88 ± 218 ml, 83 ± 165 ml). Systolic blood pressure just after CPB was higher in group B (67.9 ± 9.1 mmHg) than in group A (55.4 ± 10.3 mmHg). Postoperative ventilatory support was shorter in group B (45 ± 19 h) than in group A (68 ± 27 h). In neonatal cardiac surgery, low-priming-volume CPB circuits and DUF improve the water balance during surgery and may attenuate any inflammatory reaction, which would help preserve postoperative organ function.

元の言語英語
ページ(範囲)9-12
ページ数4
ジャーナルJournal of Artificial Organs
7
発行部数1
DOI
出版物ステータス出版済み - 4 26 2004

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

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