Val-Tyr as a natural antihypertensive dipeptide can be absorbed into the human circulatory blood system

Toshiro Matsui, Kei Tamaya, Eiji Seki, Katsuhiro Osajima, Kiyoshi Matsumoto, Terukazu Kawasaki

研究成果: Contribution to journalArticle査読

79 被引用数 (Scopus)

抄録

1. Intact absorption of the bioactive dipeptide Val-Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10-fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 ± 145 vs 159 ± 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t1/2) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 ± 688 fmol·h/mL plasma.

本文言語英語
ページ(範囲)204-208
ページ数5
ジャーナルClinical and Experimental Pharmacology and Physiology
29
3
DOI
出版ステータス出版済み - 2002

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

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