Valsartan improves the lower limit of cerebral autoregulation in rats

Junichi Takada, Setsuro Ibayashi, Hiroaki Ooboshi, Tetsuro Ago, Eiichi Ishikawa, Masahiro Kamouchi, Takanari Kitazono, Mitsuo Iida

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

The effects of angiotensin II type 1 receptor blockers (ARBs) on cerebral blood flow (CBF) autoregulation have not been fully clarified. Thus, we examined the acute effect of valsartan, the most selective ARB, on CBF autoregulation in spontaneously hypertensive rats. Intravenous administration of valsartan (0.3 mg/kg) reduced the mean arterial pressure (MAP) from 184±5 (mean±SEM) to 174±5 mmHg (p<0.001) without affecting CBF as measured by laser-Doppler flowmetry. The lower limit of CBF autoregulation (the MAP at which the CBF was 80% of the baseline value) in the valsartan-treated group (122±3 mmHg) was significantly lower than that in the control group (135±4 mmHg, p<0.05). Reverse transcribed-polymerase chain reaction and immunohistochemical staining demonstrated that both anglotensin II type 2 receptors and angiotensin II type 1 receptors (AT1Rs) were expressed in endothelial and smooth muscle cells of the rat cerebral arteries. These results suggest that specific inhibition of AT1Rs in the cerebral circulation causes the leftward shift of the lower limit of autoregulation.

元の言語英語
ページ(範囲)621-626
ページ数6
ジャーナルHypertension Research
29
発行部数8
DOI
出版物ステータス出版済み - 8 1 2006

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Valsartan
Cerebrovascular Circulation
Homeostasis
Angiotensin II Type 1 Receptor Blockers
Angiotensin Type 1 Receptor
Arterial Pressure
Laser-Doppler Flowmetry
Cerebral Arteries
Inbred SHR Rats
Intravenous Administration
Smooth Muscle Myocytes
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

これを引用

Valsartan improves the lower limit of cerebral autoregulation in rats. / Takada, Junichi; Ibayashi, Setsuro; Ooboshi, Hiroaki; Ago, Tetsuro; Ishikawa, Eiichi; Kamouchi, Masahiro; Kitazono, Takanari; Iida, Mitsuo.

:: Hypertension Research, 巻 29, 番号 8, 01.08.2006, p. 621-626.

研究成果: ジャーナルへの寄稿記事

Takada, Junichi ; Ibayashi, Setsuro ; Ooboshi, Hiroaki ; Ago, Tetsuro ; Ishikawa, Eiichi ; Kamouchi, Masahiro ; Kitazono, Takanari ; Iida, Mitsuo. / Valsartan improves the lower limit of cerebral autoregulation in rats. :: Hypertension Research. 2006 ; 巻 29, 番号 8. pp. 621-626.
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