Vascular changes in hepatocellular carcinoma: Correlation of radiologic and pathologic findings

Hiroshi Honda, Tsuyoshi Tajima, Kiyoshi Kajiyama, Toshiro Kuroiwa, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Mitsuo Shimada, Kouji Masuda

    研究成果: Contribution to journalArticle査読

    64 被引用数 (Scopus)

    抄録

    OBJECTIVE. Our objective was to analyze the hemodynamic properties and vascular supply changes in the carcinogenesis of hepatocellular carcinoma. MATERIALS AND METHODS. Ten nodules (nine patients) (one early, three early- advanced, and six advanced cases of hepatocellular carcinoma) less than 3 cm in diameter were selected from 45 patients (50 nodules) who underwent CT arteriography and CT during arterial portography. These images were correlated with histopathologic findings. Ratios of all microscopically counted (normal hepatic and abnormal) arteries, normal hepatic arteries, and portal veins in each nodule to those in the surrounding liver were calculated. RESULTS. Early hepatocellular carcinoma (one early case and early areas in three early-advanced cases) had low attenuation on CT arteriography and isoattenuation on CT during arterial portography. Advanced hepatocellular carcinoma (six advanced cases and advanced areas in three early-advanced cases) had high attenuation on CT arteriography and low attenuation on CT during arterial portography. In early hepatocellular carcinoma, the ratios of all arteries, normal hepatic arteries, and portal veins were 1.21 ± 0.07, 0.60 ± 0.07, and 0.73 ± 0.06, respectively. In advanced hepatocellular carcinoma, the ratios were 2.66 ± 0.26, 0.08 ± 0.04, and 0.07 ± 0.03, respectively. CONCLUSION. In early hepatocellular carcinoma, the combination of normal hepatic artery degeneration and preserved portal veins results in low attenuation on CT arteriography and isoattenuation on CT during arterial portography. In advanced hepatocellular carcinoma, the combination of neoplastic (abnormal) arterial development by angiogenesis and obliteration of portal veins results in high attenuation on CT arteriography and low attenuation on CT during arterial portography. These findings are a characteristic difference between early and advanced hepatocellular carcinoma.

    本文言語英語
    ページ(範囲)1213-1217
    ページ数5
    ジャーナルAmerican Journal of Roentgenology
    173
    5
    DOI
    出版ステータス出版済み - 11 1999

    All Science Journal Classification (ASJC) codes

    • Radiology Nuclear Medicine and imaging

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