Vascular endothelial growth factor and malignant transformation of a meningioma: Case report

Tadahisa Shono, Takanori Inamura, Miho Torisu, Satoshi Suzuki, Masashi Fukui

研究成果: Contribution to journalArticle

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Although meningiomas are common benign intracranial tumors which grow slowly, we occasionally encountered aggressive or malignant ones. One of these cases showed an interesting relationship to vascular endothelial growth factor (VEGF). A 39-year-old woman underwent resection of a sphenoid ridge meningioma; the residual tumor showed evidence of malignant transformation 14 years later. We immunohistochemically examined six successive surgical specimens plus the autopsy specimen of this patient's tumor for proliferative potential, vascularity, and expression of various growth factors. In the latter stage of clinical courses, proliferative potential and vascularity was seen to increase year by year. Expression of VEGF was upregulated and correlated with vascularity. On the other hand, basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF) were not overexpressed in this tumor. This case suggests that overexpression of VEGF and increased angiogenic potential might be involved in malignant transformation of meningiomas.

元の言語英語
ページ(範囲)189-193
ページ数5
ジャーナルNeurological Research
22
発行部数2
DOI
出版物ステータス出版済み - 1 1 2000

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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