Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels

Toshinori Murata, Tatsuro Ishibashi, Ahmad Khalil, Yasuaki Hata, Hiroshi Yoshikawa, Hajime Inomata

研究成果: ジャーナルへの寄稿学術誌査読

203 被引用数 (Scopus)

抄録

In rat diabetic retinas, we immunohistochemically looked for vascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF). In nondiabetic retinas, VEGF immunoreactivity was weak and restricted to the nerve fiber and ganglion cell layers. On the other hand, in diabetic retinas, VEGF immunoreactivity was markedly increased and was observed in all layers of the retina, especially in the perivascular area. Hyperpermeability of these vessels was confirmed by immunohistochemically detecting extravasation of albumin. These findings indicate that vascular endothelial growth factor plays an important role in blood-retinal barrier breakdown in diabetic retinopathy.

本文言語英語
ページ(範囲)48-52
ページ数5
ジャーナルOphthalmic Research
27
1
DOI
出版ステータス出版済み - 1995

!!!All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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