Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels

Toshinori Murata, Tatsuro Ishibashi, Ahmad Khalil, Yasuaki Hata, Hiroshi Yoshikawa, Hajime Inomata

研究成果: Contribution to journalArticle

190 引用 (Scopus)

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In rat diabetic retinas, we immunohistochemically looked for vascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF). In nondiabetic retinas, VEGF immunoreactivity was weak and restricted to the nerve fiber and ganglion cell layers. On the other hand, in diabetic retinas, VEGF immunoreactivity was markedly increased and was observed in all layers of the retina, especially in the perivascular area. Hyperpermeability of these vessels was confirmed by immunohistochemically detecting extravasation of albumin. These findings indicate that vascular endothelial growth factor plays an important role in blood-retinal barrier breakdown in diabetic retinopathy.

元の言語英語
ページ(範囲)48-52
ページ数5
ジャーナルOphthalmic Research
27
発行部数1
DOI
出版物ステータス出版済み - 1 1 1995

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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