Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer

Yoshimasa Kosaka, Akemi Kataoka, Hiroshi Yamaguchi, Hiroaki Ueo, Sayuri Akiyoshi, Norihiko Sengoku, Masaru Kuranami, Shinji Ohno, Masahiko Watanabe, Koshi Mimori, Masaki Mori

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Introduction: Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to predict distant metastasis in gastric cancer patients. However, expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood of breast cancer patients has not yet been studied.Methods: Real-time reverse transcriptase-PCR was used to analyze vascular endothelial growth factor receptor-1 mRNA expression status with respect to various clinical parameters in 515 patients with breast cancer and 25 controls.Results: Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood was higher in breast cancer patients than in controls. Increased vascular endothelial growth factor receptor-1 mRNA expression was associated with large tumor size, lymph node metastasis and clinical stage. Patients with high vascular endothelial growth factor receptor-1 mRNA expression also experienced a poorer survival rate than those with low expression levels, including those patients with triple-negative type and luminal-HER2(-) type disease.Conclusions: Expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful for prediction of poor prognosis in breast cancer, especially in patients with triple-negative type and luminal-HER2(-) type disease.

本文言語英語
論文番号R140
ジャーナルBreast Cancer Research
14
5
DOI
出版ステータス出版済み - 10 31 2012

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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