Vascular remodeling and angiotensin II

M. Takemoto, K. Egashira

    研究成果: Contribution to journalReview article査読

    2 被引用数 (Scopus)

    抄録

    Numerous pharmacological approaches have failed to modify the high incidence of restenosis after balloon coronary angioplasty. This inability to alter the restenosis process was caused in part by our incomplete understanding of its pathology. Neointimal formation and geometric remodeling cause the restenosis after angioplasty. The development of restenosis involves vascular smooth muscle cells (VSMCs) migration and proliferation. Angiotensin II has been shown to stimulate the growth of VSMCs via an action on the angiotensin II AT1 receptor subtype. Angiotensin II AT1 receptor antagonists can block the angiotensin II-induced these actions. Angiotensin II AT1 receptor antagonists may block the restenosis after balloon coronary angioplasty.

    本文言語英語
    ページ(範囲)1158-1163
    ページ数6
    ジャーナルNippon rinsho. Japanese journal of clinical medicine
    57
    5
    出版ステータス出版済み - 5 1999

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    フィンガープリント 「Vascular remodeling and angiotensin II」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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