VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker

Tsuyoshi Sugiura, Yoshiko Inoue, Ryosuke Matsuki, Kotaro Ishii, Miho Takahashi, Masakazu Abe, Kanemitsu Shirasuna

研究成果: ジャーナルへの寄稿学術誌査読

90 被引用数 (Scopus)

抄録

The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the expression of VEGF-C and VEGF-D in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (160 cases) were examined for lymphatic vessel density (LVD) and the expression of VEGF-C and VEGF-D immunohistochemically. The levels of VEGF-C and VEGF-D expression and LVD were significantly associated with lymph node metastasis (p<0.001). The expression of VEGF-C and VEGF-D increased the LVD significantly (p<0.001). Multivariate analysis showed that VEGF-C expression and LVD were significantly associated with lymph node metastasis (p<0.001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC.

本文言語英語
ページ(範囲)673-680
ページ数8
ジャーナルInternational journal of oncology
34
3
DOI
出版ステータス出版済み - 2009

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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