Venodilator effects of adenosine triphosphate and sodium nitroprusside; Comparisons during controlled hypotension

Sumio Hoka, Akira Takeshita, Kazuko Aishima, Hideki Higashi, Shousuke Takahashi, Junichi Yoshitake

研究成果: ジャーナルへの寄稿記事

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Adenosine triphosphate as well as sodium nitroprusside has been used for hypotensive anesthesia. The purpose of this study was to examine the possibility that two hypotensive drugs may exert different effects on venous capacitance during controlled hypotension. In rats anesthetized with ketamine, mean arterial pressure was lowered to 50 mmHg by intravenous infusion of adenosine triphosphate or sodium nitroprusside. Venous capacitance was assessed before and during induced hypotension by measuring the mean circulatory filling pressure (MCFP). MCFP was measured after briefly arresting the circulation by inflating an indwelling balloon in the right atrium. MCFP was lower during adenosine triphosphate-induced as well as sodium nitroprusside-induced hypotension as compared with the respective value at control"(P<O.01 for adenosine triphosphate and sodium nitroprusside). However, the decrease in MCFP by adenosine triphosphate (0.8±0.1 mmHg) was less (P<O.Ol) than that by sodium nitroprusside (2.3±0.3 mmHg). These results suggest that at a comparable level of arterial hypotension venodilator effect of adenosine triphosphate was less than that of sodium nitroprusside. Less venodilatation during adenosine triphosphate-induced hypotension may contribute to the maintenance of cardiac output during hypotensive anesthesia.

元の言語英語
ページ(範囲)143-147
ページ数5
ジャーナルJournal of Anesthesia
1
発行部数2
DOI
出版物ステータス出版済み - 9 1 1987

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All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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