Ventilation/perfusion imaging of the lung using ultra-short echo time (UTE) MRI in an animal model of pulmonary embolism

Osamu Togao, Yoshiharu Ohno, Ivan Dimitrov, Connie C. Hsia, Masaya Takahashi

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

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Purpose: To test the feasibility of ultra-short echo time (UTE) MRI for assessment of regional pulmonary ventilation/perfusion in a standard 3 Tesla clinical MRI system. Materials and Methods: MRI of the lungs was conducted with an optimized three-dimensional UTE sequence in normal rats and in a rat model of pulmonary embolism (PE) induced by a blood clot. Changes in signal intensities (SIs) due to inhalation of molecular oxygen or intravenous (i.v.) injection of Gd, which represents the distribution of ventilation and perfusion, respectively, were assessed in the lung parenchyma. Results: The UTE MRI with a TE of 100 μs could detect and map the changes in SI of the lung parenchyma due to the inhalation of 100% oxygen or i.v. injection of Gd in normal rats. Reduced T1 resulting from oxygen inhalation was also quantified. These changes were not observed on the images that were obtained simultaneously with a conventional range of TE (2.3 ms). Furthermore, the method could delineate the embolized lesions where the lung ventilation and perfusion were mismatched in a rat model with PE. Conclusion: These results show the feasibility and diagnostic potential of UTE MRI for the assessment of pulmonary ventilation and perfusion which is essential for the evaluation of a variety of lung diseases.

元の言語英語
ページ(範囲)539-546
ページ数8
ジャーナルJournal of Magnetic Resonance Imaging
34
発行部数3
DOI
出版物ステータス出版済み - 9 1 2011
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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