Viral diversity limits immune diversity in asymptomatic phase of HIV infection

Shingo Iwami, Shinji Nakaoka, Yasuhiro Takeuchi

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number "immune diversity threshold". Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.

本文言語英語
ページ(範囲)332-341
ページ数10
ジャーナルTheoretical Population Biology
73
3
DOI
出版ステータス出版済み - 5 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

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