Viral infections in asthma and COPD

Koichiro Matsumoto, Hiromasa Inoue

研究成果: ジャーナルへの寄稿評論記事

33 引用 (Scopus)

抄録

Airway viral infections are associated with the pathogenesis of asthma and COPD. It has been argued that respiratory syncytial virus (RSV) infection in infancy is a probable causal factor in the development of pediatric asthma. RSV infections tend to induce Th2-biased immune responses in the host airways. RSV infection, atopy, and low pulmonary function in neonates may work synergistically toward the development of pediatric asthma. Human rhinovirus (HRV) is a representative virus associated with the exacerbation of asthma in both children and adults. Viral infections trigger innate immune responses including granulocytic inflammation and worsen the underlying inflammation due to asthma and COPD. The innate immune responses involve type-I and -III interferon (IFN) production, which plays an important role in anti-viral responses, and the airway epithelia of asthmatics reportedly exhibit defects in the virus-induced IFN responses, which renders these individuals more susceptible to viral infection. A similarly impaired IFN response is seen in COPD, and several investigators propose that latent adenoviral infection may be involved in COPD development. Persistent RSV infections were detected in a sub-population of patients with COPD and were associated with the accelerated decline of lung function. The virus-induced upregulation of co-inhibitory molecules in the airway epithelium partly accounts for the persistent infections. Experimental animal models for virus-asthma/COPD interactions have shed light on the underlying immune mechanisms and are expected to help develop novel approaches to treat respiratory diseases.

元の言語英語
ページ(範囲)92-100
ページ数9
ジャーナルRespiratory Investigation
52
発行部数2
DOI
出版物ステータス出版済み - 3 2014

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Virus Diseases
Chronic Obstructive Pulmonary Disease
Respiratory Syncytial Virus Infections
Asthma
Viruses
Innate Immunity
Interferons
Epithelium
Pediatrics
Inflammation
Rhinovirus
Lung
Interferon Type I
Infection
Up-Regulation
Animal Models
Research Personnel
Newborn Infant
Population

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

これを引用

Viral infections in asthma and COPD. / Matsumoto, Koichiro; Inoue, Hiromasa.

:: Respiratory Investigation, 巻 52, 番号 2, 03.2014, p. 92-100.

研究成果: ジャーナルへの寄稿評論記事

Matsumoto, Koichiro ; Inoue, Hiromasa. / Viral infections in asthma and COPD. :: Respiratory Investigation. 2014 ; 巻 52, 番号 2. pp. 92-100.
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