Visualization of electroporation-induced temperature rise using temperature-sensitive ink

Kosaku Kurata, Takashi Yoshii, Satoru Uchida, Takanobu Fukunaga, Hiroshi Takamatsu

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Irreversible electroporation (IRE) is attracting attention as a new technique to treat tumors, in which electric pulses over a certain threshold perforate the cell membrane and induce necrotic cell death. Since the electric pulses potentially generate the Joule heating around electrodes, successful IRE needs to apply a pulsed voltage high enough for the irreversible perforation yet minimizes the thermal effect on the extracellular matrix in the surrounding tissue. The temperature rise around the electrodes is therefore one of the most important concerns in the IRE. However, no experimental evidence has been reported for the temperature rise because of extremely short pulses used in the IRE. The aim of this study was therefore to establish a new method to detect the temperature rise during the IRE. A key technique is to use temperature- sensitive ink to visualize in situ instantaneous temperature rise. Chromatic change of the ink that depends on the temperature was preliminarily calibrated by a transient short-hot-wire technique combined with color analysis of the ink, and then utilized to determine the temperature distribution after electroporation. The maximum temperature rise was thus successfully visualized after the electroporation using agar gel as a tissue phantom. Our method is useful for direct evaluation of a risk of thermal damage and provides experimental evidence for theoretical study.

元の言語英語
ページ(範囲)7207-7212
ページ数6
ジャーナルInternational Journal of Heat and Mass Transfer
55
発行部数23-24
DOI
出版物ステータス出版済み - 1 1 2012

Fingerprint

inks
Ink
Visualization
electric pulses
Temperature
temperature
Tissue
perforation
Electrodes
Joule heating
electrodes
Cell death
Cell membranes
death
Thermal effects
Agar
temperature effects
Tumors
high voltages
Temperature distribution

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

これを引用

Visualization of electroporation-induced temperature rise using temperature-sensitive ink. / Kurata, Kosaku; Yoshii, Takashi; Uchida, Satoru; Fukunaga, Takanobu; Takamatsu, Hiroshi.

:: International Journal of Heat and Mass Transfer, 巻 55, 番号 23-24, 01.01.2012, p. 7207-7212.

研究成果: ジャーナルへの寄稿記事

@article{e6df85444e1447d19f78090f25544f16,
title = "Visualization of electroporation-induced temperature rise using temperature-sensitive ink",
abstract = "Irreversible electroporation (IRE) is attracting attention as a new technique to treat tumors, in which electric pulses over a certain threshold perforate the cell membrane and induce necrotic cell death. Since the electric pulses potentially generate the Joule heating around electrodes, successful IRE needs to apply a pulsed voltage high enough for the irreversible perforation yet minimizes the thermal effect on the extracellular matrix in the surrounding tissue. The temperature rise around the electrodes is therefore one of the most important concerns in the IRE. However, no experimental evidence has been reported for the temperature rise because of extremely short pulses used in the IRE. The aim of this study was therefore to establish a new method to detect the temperature rise during the IRE. A key technique is to use temperature- sensitive ink to visualize in situ instantaneous temperature rise. Chromatic change of the ink that depends on the temperature was preliminarily calibrated by a transient short-hot-wire technique combined with color analysis of the ink, and then utilized to determine the temperature distribution after electroporation. The maximum temperature rise was thus successfully visualized after the electroporation using agar gel as a tissue phantom. Our method is useful for direct evaluation of a risk of thermal damage and provides experimental evidence for theoretical study.",
author = "Kosaku Kurata and Takashi Yoshii and Satoru Uchida and Takanobu Fukunaga and Hiroshi Takamatsu",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.ijheatmasstransfer.2012.07.038",
language = "English",
volume = "55",
pages = "7207--7212",
journal = "International Journal of Heat and Mass Transfer",
issn = "0017-9310",
publisher = "Elsevier Limited",
number = "23-24",

}

TY - JOUR

T1 - Visualization of electroporation-induced temperature rise using temperature-sensitive ink

AU - Kurata, Kosaku

AU - Yoshii, Takashi

AU - Uchida, Satoru

AU - Fukunaga, Takanobu

AU - Takamatsu, Hiroshi

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Irreversible electroporation (IRE) is attracting attention as a new technique to treat tumors, in which electric pulses over a certain threshold perforate the cell membrane and induce necrotic cell death. Since the electric pulses potentially generate the Joule heating around electrodes, successful IRE needs to apply a pulsed voltage high enough for the irreversible perforation yet minimizes the thermal effect on the extracellular matrix in the surrounding tissue. The temperature rise around the electrodes is therefore one of the most important concerns in the IRE. However, no experimental evidence has been reported for the temperature rise because of extremely short pulses used in the IRE. The aim of this study was therefore to establish a new method to detect the temperature rise during the IRE. A key technique is to use temperature- sensitive ink to visualize in situ instantaneous temperature rise. Chromatic change of the ink that depends on the temperature was preliminarily calibrated by a transient short-hot-wire technique combined with color analysis of the ink, and then utilized to determine the temperature distribution after electroporation. The maximum temperature rise was thus successfully visualized after the electroporation using agar gel as a tissue phantom. Our method is useful for direct evaluation of a risk of thermal damage and provides experimental evidence for theoretical study.

AB - Irreversible electroporation (IRE) is attracting attention as a new technique to treat tumors, in which electric pulses over a certain threshold perforate the cell membrane and induce necrotic cell death. Since the electric pulses potentially generate the Joule heating around electrodes, successful IRE needs to apply a pulsed voltage high enough for the irreversible perforation yet minimizes the thermal effect on the extracellular matrix in the surrounding tissue. The temperature rise around the electrodes is therefore one of the most important concerns in the IRE. However, no experimental evidence has been reported for the temperature rise because of extremely short pulses used in the IRE. The aim of this study was therefore to establish a new method to detect the temperature rise during the IRE. A key technique is to use temperature- sensitive ink to visualize in situ instantaneous temperature rise. Chromatic change of the ink that depends on the temperature was preliminarily calibrated by a transient short-hot-wire technique combined with color analysis of the ink, and then utilized to determine the temperature distribution after electroporation. The maximum temperature rise was thus successfully visualized after the electroporation using agar gel as a tissue phantom. Our method is useful for direct evaluation of a risk of thermal damage and provides experimental evidence for theoretical study.

UR - http://www.scopus.com/inward/record.url?scp=84865744174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865744174&partnerID=8YFLogxK

U2 - 10.1016/j.ijheatmasstransfer.2012.07.038

DO - 10.1016/j.ijheatmasstransfer.2012.07.038

M3 - Article

AN - SCOPUS:84865744174

VL - 55

SP - 7207

EP - 7212

JO - International Journal of Heat and Mass Transfer

JF - International Journal of Heat and Mass Transfer

SN - 0017-9310

IS - 23-24

ER -