Vitamin B 12 derivatives as activators of soluble guanylyl cyclase

Keith Ó Proinsias, Daniel T. Gryko, Yoshio Hisaeda, Emil Martin, Jonathan L. Sessler, Dorota Gryko

    研究成果: ジャーナルへの寄稿学術誌査読

    4 被引用数 (Scopus)

    抄録

    Various newly prepared and previously known vitamin B 12 derivatives have been studied as potential soluble guanylyl cyclase (sGC) activators. All compounds tested were found to activate the sGC enzyme, although to differing extents. The best results were obtained with the derivatives synthesized from c-lactone and possessing aliphatic amides in the c- and d-positions.

    本文言語英語
    ページ(範囲)8943-8947
    ページ数5
    ジャーナルJournal of Medicinal Chemistry
    55
    20
    DOI
    出版ステータス出版済み - 10月 25 2012

    !!!All Science Journal Classification (ASJC) codes

    • 分子医療
    • 創薬

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