Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Ying Lin; Yan Meng; Yan Xia Wang; Juan Luo; Susumu Katsuma; Cong Wen Yang; Yutaka Banno; Takahiro Kusakabe; Toru Shimada; Qing You Xia

doi:10.1074/jbc.M113.462556

Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

Ying Lin, Yan Meng, Yan Xia Wang, Juan Luo, Susumu Katsuma, Cong Wen Yang, Yutaka Banno, Takahiro Kusakabe, Toru Shimada, Qing You Xia

研究成果: Contribution to journal › Article › 査読

52 被引用数 (Scopus)

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Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

本文言語	英語
ページ（範囲）	13345-13355
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	288
号	19
DOI	https://doi.org/10.1074/jbc.M113.462556
出版ステータス	出版済み - 5 10 2013

All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

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10.1074/jbc.M113.462556

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Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori. / Lin, Ying; Meng, Yan; Wang, Yan Xia; Luo, Juan; Katsuma, Susumu; Yang, Cong Wen; Banno, Yutaka ; Kusakabe, Takahiro; Shimada, Toru; Xia, Qing You.

In: Journal of Biological Chemistry, Vol. 288, No. 19, 10.05.2013, p. 13345-13355.

研究成果: Contribution to journal › Article › 査読

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title = "Vitellogenin receptor mutation leads to the oogenesis mutant phenotype {"}scanty vitellin{"} of the silkworm, bombyx mori",

abstract = "Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.",

author = "Ying Lin and Yan Meng and Wang, {Yan Xia} and Juan Luo and Susumu Katsuma and Yang, {Cong Wen} and Yutaka Banno and Takahiro Kusakabe and Toru Shimada and Xia, {Qing You}",

year = "2013",

month = may,

day = "10",

doi = "10.1074/jbc.M113.462556",

language = "English",

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journal = "Journal of Biological Chemistry",

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T1 - Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

AU - Lin, Ying

AU - Meng, Yan

AU - Wang, Yan Xia

AU - Luo, Juan

AU - Katsuma, Susumu

AU - Yang, Cong Wen

AU - Banno, Yutaka

AU - Kusakabe, Takahiro

AU - Shimada, Toru

AU - Xia, Qing You

PY - 2013/5/10

Y1 - 2013/5/10

N2 - Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

AB - Background: The vitellogenin receptor (VgR) mediates the uptake of vitellogenin (Vg) from the hemolymph by developing oocytes. Results: VgR with the mutational EGF1 domain can bind ligand proteins but cannot be dissociated under acidic conditions. The mutant is lethal in embryos. Conclusion: Bombyx mori VgR (BmVgR) has an important role in egg formation and embryonic development. Significance: BmVgR is a potential target for pest control.

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Vitellogenin receptor mutation leads to the oogenesis mutant phenotype "scanty vitellin" of the silkworm, bombyx mori

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