Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion

A potential diagnostic pitfall

Kenji Yorita, Yuki Togashi, Hideyuki Nakagawa, Katsushi Miyazaki, Seiji Sakata, Satoko Baba, Kengo Takeuchi, Yoshihiro Hayashi, Ichiro Murakami, Naoto Kuroda, Yoshinao Oda, Kenichi Kouhashi, Yuichi Yamada, Daisuke Kiyozawa, Michael Michal, Michal Michal

研究成果: ジャーナルへの寄稿記事

抄録

A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mucoid stroma. Vacuolated cells were also seen. Lymphoplasmacytic infiltrate was largely undetectable. A vocal cord polyp was first suspected, but well-differentiated liposarcoma and inflammatory myofibroblastic tumor (IMT) were included in the differential diagnoses. The tumor cells were positive for anaplastic lymphoma kinase (ALK), calponin, and vimentin, and negative for other smooth muscle markers by immunohistochemistry. Structures resembling myofibroblasts were not observed by electron microscopy, which confirmed abundant rough endoplasmic reticulum in the tumor cells and accumulated lipid droplets in some tumor cells. ALK gene rearrangement was detected by fluorescence in situ hybridization, and TIMP3–ALK fusion was confirmed by 5′ rapid amplification of cDNA ends. We diagnosed the lesion as an IMT, and an ALK-rearranged stellate cell tumor may be postulated. This is the first report of a fusion partner gene of ALK in a case of laryngeal IMT.

元の言語英語
ページ(範囲)366-371
ページ数6
ジャーナルPathology International
69
発行部数6
DOI
出版物ステータス出版済み - 1 1 2019

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Vocal Cords
Neoplasms
Polyps
Stellate Ganglion
Hoarseness
Liposarcoma
Myofibroblasts
Gene Rearrangement
Rough Endoplasmic Reticulum
Gene Fusion
Vimentin
Fluorescence In Situ Hybridization
Smooth Muscle
Electron Microscopy
Differential Diagnosis
Complementary DNA
Immunohistochemistry
anaplastic lymphoma kinase

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion : A potential diagnostic pitfall. / Yorita, Kenji; Togashi, Yuki; Nakagawa, Hideyuki; Miyazaki, Katsushi; Sakata, Seiji; Baba, Satoko; Takeuchi, Kengo; Hayashi, Yoshihiro; Murakami, Ichiro; Kuroda, Naoto; Oda, Yoshinao; Kouhashi, Kenichi; Yamada, Yuichi; Kiyozawa, Daisuke; Michal, Michael; Michal, Michal.

:: Pathology International, 巻 69, 番号 6, 01.01.2019, p. 366-371.

研究成果: ジャーナルへの寄稿記事

Yorita, K, Togashi, Y, Nakagawa, H, Miyazaki, K, Sakata, S, Baba, S, Takeuchi, K, Hayashi, Y, Murakami, I, Kuroda, N, Oda, Y, Kouhashi, K, Yamada, Y, Kiyozawa, D, Michal, M & Michal, M 2019, 'Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion: A potential diagnostic pitfall', Pathology International, 巻. 69, 番号 6, pp. 366-371. https://doi.org/10.1111/pin.12796
Yorita, Kenji ; Togashi, Yuki ; Nakagawa, Hideyuki ; Miyazaki, Katsushi ; Sakata, Seiji ; Baba, Satoko ; Takeuchi, Kengo ; Hayashi, Yoshihiro ; Murakami, Ichiro ; Kuroda, Naoto ; Oda, Yoshinao ; Kouhashi, Kenichi ; Yamada, Yuichi ; Kiyozawa, Daisuke ; Michal, Michael ; Michal, Michal. / Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3–ALK fusion : A potential diagnostic pitfall. :: Pathology International. 2019 ; 巻 69, 番号 6. pp. 366-371.
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