Water-proton relaxivities of DNA oligomers carrying TEMPO radicals

Yuichiro Sato, Hiroyuki Hayashi, Manami Okazaki, Mariko Aso, Satoru Karasawa, Shoji Ueki, Hiroshi Suemune, Noboru Koga

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抜粋

5-Uridine derivative carrying a TEMPO radical (UST) was prepared and its single strand (ssUST) and a double strand (dsUST) with its complementary strand were obtained. Similarly, single strands carrying two and five radicals (ssUST2 and ssUST5, respectively) and the corresponding doubles trands (dsUST2 and dsUST5) were prepared. Their electron paramagnetic resonance (EPR) spectra showed typical anisotropic broadening in the high field line. The rotational correlation times, τR, estimated by analyzing the EPR spectra are 1.1 × 10-10, 5.9 × 10-10, and 14 × 10-10 s for UST, ssUSTm, and dsUSTm, respectively. The water-proton relaxivities, r1 and r2, at 25 MHz, 0.59 T, and 25°C, also increased in the same order and the r1 values were 0.26, 0.41, and 0.56 mM-1 s-1 for UST, ssUSTm, and dsUSTm, respectively. The r1 values of 1.00 and 2.06 mM-1 s -1 for dsUST2 and dsUST5, respectively, were obtained.

元の言語英語
ページ(範囲)1055-1058
ページ数4
ジャーナルMagnetic Resonance in Chemistry
46
発行部数11
DOI
出版物ステータス出版済み - 11 1 2008

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)

これを引用

Sato, Y., Hayashi, H., Okazaki, M., Aso, M., Karasawa, S., Ueki, S., ... Koga, N. (2008). Water-proton relaxivities of DNA oligomers carrying TEMPO radicals. Magnetic Resonance in Chemistry, 46(11), 1055-1058. https://doi.org/10.1002/mrc.2310