Water structure and polymer dynamics in hydrated blood compatible polymers

Yuko Miwa, Masaru Tanaka, Akira Mochizuki

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Biomaterials with good blood compatibility are essential for new medical devices and/or therapies. Thus, there are many attempts to improve their performance for blood. To this end, biomaterials with a variety of surfaces have been proposed and some of them are already in clinical use. These surfaces can be classified into four groups; 1) super-hydrophilic surface, 2) micro-phase-separated domain surface, 3) biomembrane like surface and 4) bioactive-molecules incorporating surface. It is not clear, however, how these surfaces exhibit good blood compatibility except the case of 4). Recently, we found that poly (2-methoxyethyl acrylate) (PMEA), which does not belong to any of the classes mentioned above, exhibits excellent blood compatibility, but the mechanism of its good performance has not yet been fully understood. In order to gain an insight into its good performance, we have investigated the water structure in PMEA, and also polymer dynamics by solid-state NMR. Here, we discuss the role of water structure and polymer dynamics in determining good-compatibility of biomaterials from the viewpoint of water structure on the basis of various reports about the water structure in polymers investigated by DSC, FT-IR and NMR.

本文言語英語
ページ(範囲)133-146
ページ数14
ジャーナルKOBUNSHI RONBUNSHU
68
4
DOI
出版ステータス出版済み - 4月 1 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 化学工学(その他)
  • 材料科学(その他)
  • 環境科学(全般)
  • ポリマーおよびプラスチック

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