WECHE

A novel hematopoietic regulatory factor

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

元の言語英語
ページ(範囲)141-150
ページ数10
ジャーナルImmunity
12
発行部数2
出版物ステータス出版済み - 1 1 2000
外部発表Yes

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Erythroid Cells
Chemokines
Bone Marrow Cells
B-Lymphocytes
Stem Cells
Endothelial Cells
Cell Line
Interleukin-7
Yolk Sac
Erythroid Precursor Cells
Interleukin-3
Liver
Myeloid Cells
Gene Expression
Growth
N-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

これを引用

Ohneda, O., Ohneda, K., Nomiyama, H., Zheng, Z., Gold, S. A., Arai, F., ... Lasky, L. A. (2000). WECHE: A novel hematopoietic regulatory factor. Immunity, 12(2), 141-150.

WECHE : A novel hematopoietic regulatory factor. / Ohneda, Osamu; Ohneda, Kinuko; Nomiyama, Hisayuki; Zheng, Zhong; Gold, Steven A.; Arai, Fumio; Miyamoto, Takeshi; Taillon, Bruce E.; McIndoe, Richard A.; Shimkets, Richard A.; Lewin, David A.; Suda, Toshio; Lasky, Laurence A.

:: Immunity, 巻 12, 番号 2, 01.01.2000, p. 141-150.

研究成果: ジャーナルへの寄稿記事

Ohneda, O, Ohneda, K, Nomiyama, H, Zheng, Z, Gold, SA, Arai, F, Miyamoto, T, Taillon, BE, McIndoe, RA, Shimkets, RA, Lewin, DA, Suda, T & Lasky, LA 2000, 'WECHE: A novel hematopoietic regulatory factor', Immunity, 巻. 12, 番号 2, pp. 141-150.
Ohneda O, Ohneda K, Nomiyama H, Zheng Z, Gold SA, Arai F その他. WECHE: A novel hematopoietic regulatory factor. Immunity. 2000 1 1;12(2):141-150.
Ohneda, Osamu ; Ohneda, Kinuko ; Nomiyama, Hisayuki ; Zheng, Zhong ; Gold, Steven A. ; Arai, Fumio ; Miyamoto, Takeshi ; Taillon, Bruce E. ; McIndoe, Richard A. ; Shimkets, Richard A. ; Lewin, David A. ; Suda, Toshio ; Lasky, Laurence A. / WECHE : A novel hematopoietic regulatory factor. :: Immunity. 2000 ; 巻 12, 番号 2. pp. 141-150.
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AU - Arai, Fumio

AU - Miyamoto, Takeshi

AU - Taillon, Bruce E.

AU - McIndoe, Richard A.

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