Weight reduction decreases soluble cellular adhesion molecules in obese women

Hiroyuki Ito, Akiko Ohshima, Misako Inoue, Naoko Ohto, Kazuta Nakasuga, Yoshikazu Kaji, Toru Maruyama, Kazuo Nishioka

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

抄録

1. Obesity is known to increase the risk for atherosclerotic diseases. Serum levels of cellular adhesion molecules are reported to be indices of atherosclerosis. The aim of the present study was to assess the effect of weight reduction on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin). 2. Eighteen non-diabetic normotensive obese women participated in a 3 month lifestyle-modification programme (intervention group). The programme consisted of lectures on diet, exercise sessions and behavioural modification by weight charting. Fourteen women who did not enter the programme served as controls. Body fat mass (FM) was measured by dual-energy X-ray absorptiometry. Soluble ICAM-1 and sE-selectin were measured by ELISA. 3. After 3 months, sICAM-1 and sE-selectin, as well as body FM, decreased in the intervention group (P < 0.001), while no changes were observed in the control group. The baseline sE-selectin was positively correlated with total body FM, trunk FM and percentage body fat (r = 0.50-0.57; P < 0.01), but not with leg FM. The change in sE-selectin was also correlated with changes in total body FM and trunk FM (both r = 0.46; P < 0.01). Baseline sICAM-1 was not significantly correlated with these variables. The associations between changes in sICAM-1 and changes in total body FM or trunk FM were of borderline significance (both r = 0.34; P = 0.06). Linear regression analysis indicated that the change in sE-selectin was explained by the change in trunk FM (R2 = 0.18; P < 0.01). 4. Soluble ICAM-1 and sE-selectin were positively correlated with obesity, especially with central obesity. Weight reduction resulted in decreases in soluble adhesion molecules, which may suggest a downregulation of endothelial activation.

元の言語英語
ページ(範囲)399-404
ページ数6
ジャーナルClinical and Experimental Pharmacology and Physiology
29
発行部数5-6
DOI
出版物ステータス出版済み - 2002

Fingerprint

E-Selectin
Intercellular Adhesion Molecule-1
Weight Loss
Adipose Tissue
Fats
Obesity
Abdominal Obesity
Photon Absorptiometry
Life Style
Linear Models
Leg
Atherosclerosis
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Exercise
Diet
Weights and Measures
Control Groups
Serum

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

Weight reduction decreases soluble cellular adhesion molecules in obese women. / Ito, Hiroyuki; Ohshima, Akiko; Inoue, Misako; Ohto, Naoko; Nakasuga, Kazuta; Kaji, Yoshikazu; Maruyama, Toru; Nishioka, Kazuo.

:: Clinical and Experimental Pharmacology and Physiology, 巻 29, 番号 5-6, 2002, p. 399-404.

研究成果: ジャーナルへの寄稿記事

Ito, Hiroyuki ; Ohshima, Akiko ; Inoue, Misako ; Ohto, Naoko ; Nakasuga, Kazuta ; Kaji, Yoshikazu ; Maruyama, Toru ; Nishioka, Kazuo. / Weight reduction decreases soluble cellular adhesion molecules in obese women. :: Clinical and Experimental Pharmacology and Physiology. 2002 ; 巻 29, 番号 5-6. pp. 399-404.
@article{69d17aa41fb844139b12a87510ad042c,
title = "Weight reduction decreases soluble cellular adhesion molecules in obese women",
abstract = "1. Obesity is known to increase the risk for atherosclerotic diseases. Serum levels of cellular adhesion molecules are reported to be indices of atherosclerosis. The aim of the present study was to assess the effect of weight reduction on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin). 2. Eighteen non-diabetic normotensive obese women participated in a 3 month lifestyle-modification programme (intervention group). The programme consisted of lectures on diet, exercise sessions and behavioural modification by weight charting. Fourteen women who did not enter the programme served as controls. Body fat mass (FM) was measured by dual-energy X-ray absorptiometry. Soluble ICAM-1 and sE-selectin were measured by ELISA. 3. After 3 months, sICAM-1 and sE-selectin, as well as body FM, decreased in the intervention group (P < 0.001), while no changes were observed in the control group. The baseline sE-selectin was positively correlated with total body FM, trunk FM and percentage body fat (r = 0.50-0.57; P < 0.01), but not with leg FM. The change in sE-selectin was also correlated with changes in total body FM and trunk FM (both r = 0.46; P < 0.01). Baseline sICAM-1 was not significantly correlated with these variables. The associations between changes in sICAM-1 and changes in total body FM or trunk FM were of borderline significance (both r = 0.34; P = 0.06). Linear regression analysis indicated that the change in sE-selectin was explained by the change in trunk FM (R2 = 0.18; P < 0.01). 4. Soluble ICAM-1 and sE-selectin were positively correlated with obesity, especially with central obesity. Weight reduction resulted in decreases in soluble adhesion molecules, which may suggest a downregulation of endothelial activation.",
author = "Hiroyuki Ito and Akiko Ohshima and Misako Inoue and Naoko Ohto and Kazuta Nakasuga and Yoshikazu Kaji and Toru Maruyama and Kazuo Nishioka",
year = "2002",
doi = "10.1046/j.1440-1681.2002.03672.x",
language = "English",
volume = "29",
pages = "399--404",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "5-6",

}

TY - JOUR

T1 - Weight reduction decreases soluble cellular adhesion molecules in obese women

AU - Ito, Hiroyuki

AU - Ohshima, Akiko

AU - Inoue, Misako

AU - Ohto, Naoko

AU - Nakasuga, Kazuta

AU - Kaji, Yoshikazu

AU - Maruyama, Toru

AU - Nishioka, Kazuo

PY - 2002

Y1 - 2002

N2 - 1. Obesity is known to increase the risk for atherosclerotic diseases. Serum levels of cellular adhesion molecules are reported to be indices of atherosclerosis. The aim of the present study was to assess the effect of weight reduction on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin). 2. Eighteen non-diabetic normotensive obese women participated in a 3 month lifestyle-modification programme (intervention group). The programme consisted of lectures on diet, exercise sessions and behavioural modification by weight charting. Fourteen women who did not enter the programme served as controls. Body fat mass (FM) was measured by dual-energy X-ray absorptiometry. Soluble ICAM-1 and sE-selectin were measured by ELISA. 3. After 3 months, sICAM-1 and sE-selectin, as well as body FM, decreased in the intervention group (P < 0.001), while no changes were observed in the control group. The baseline sE-selectin was positively correlated with total body FM, trunk FM and percentage body fat (r = 0.50-0.57; P < 0.01), but not with leg FM. The change in sE-selectin was also correlated with changes in total body FM and trunk FM (both r = 0.46; P < 0.01). Baseline sICAM-1 was not significantly correlated with these variables. The associations between changes in sICAM-1 and changes in total body FM or trunk FM were of borderline significance (both r = 0.34; P = 0.06). Linear regression analysis indicated that the change in sE-selectin was explained by the change in trunk FM (R2 = 0.18; P < 0.01). 4. Soluble ICAM-1 and sE-selectin were positively correlated with obesity, especially with central obesity. Weight reduction resulted in decreases in soluble adhesion molecules, which may suggest a downregulation of endothelial activation.

AB - 1. Obesity is known to increase the risk for atherosclerotic diseases. Serum levels of cellular adhesion molecules are reported to be indices of atherosclerosis. The aim of the present study was to assess the effect of weight reduction on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin). 2. Eighteen non-diabetic normotensive obese women participated in a 3 month lifestyle-modification programme (intervention group). The programme consisted of lectures on diet, exercise sessions and behavioural modification by weight charting. Fourteen women who did not enter the programme served as controls. Body fat mass (FM) was measured by dual-energy X-ray absorptiometry. Soluble ICAM-1 and sE-selectin were measured by ELISA. 3. After 3 months, sICAM-1 and sE-selectin, as well as body FM, decreased in the intervention group (P < 0.001), while no changes were observed in the control group. The baseline sE-selectin was positively correlated with total body FM, trunk FM and percentage body fat (r = 0.50-0.57; P < 0.01), but not with leg FM. The change in sE-selectin was also correlated with changes in total body FM and trunk FM (both r = 0.46; P < 0.01). Baseline sICAM-1 was not significantly correlated with these variables. The associations between changes in sICAM-1 and changes in total body FM or trunk FM were of borderline significance (both r = 0.34; P = 0.06). Linear regression analysis indicated that the change in sE-selectin was explained by the change in trunk FM (R2 = 0.18; P < 0.01). 4. Soluble ICAM-1 and sE-selectin were positively correlated with obesity, especially with central obesity. Weight reduction resulted in decreases in soluble adhesion molecules, which may suggest a downregulation of endothelial activation.

UR - http://www.scopus.com/inward/record.url?scp=0036090710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036090710&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1681.2002.03672.x

DO - 10.1046/j.1440-1681.2002.03672.x

M3 - Article

C2 - 12010183

AN - SCOPUS:0036090710

VL - 29

SP - 399

EP - 404

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 5-6

ER -