Werner interacting protein 1 promotes binding of werner protein to template-primer DNA

Makoto Kanamori, Masayuki Seki, Akari Yoshimura, Toshiki Tsurimoto, Shusuke Tada, Takemi Enomoto

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.

元の言語英語
ページ(範囲)1314-1318
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
34
発行部数8
DOI
出版物ステータス出版済み - 8 1 2011

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DNA Primers
Carrier Proteins
Proteins
DNA
Werner Syndrome
DNA Helicases
Adenosine Triphosphate
Escherichia coli

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

これを引用

Werner interacting protein 1 promotes binding of werner protein to template-primer DNA. / Kanamori, Makoto; Seki, Masayuki; Yoshimura, Akari; Tsurimoto, Toshiki; Tada, Shusuke; Enomoto, Takemi.

:: Biological and Pharmaceutical Bulletin, 巻 34, 番号 8, 01.08.2011, p. 1314-1318.

研究成果: ジャーナルへの寄稿記事

Kanamori, Makoto ; Seki, Masayuki ; Yoshimura, Akari ; Tsurimoto, Toshiki ; Tada, Shusuke ; Enomoto, Takemi. / Werner interacting protein 1 promotes binding of werner protein to template-primer DNA. :: Biological and Pharmaceutical Bulletin. 2011 ; 巻 34, 番号 8. pp. 1314-1318.
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