抄録
Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1314-1318 |
| ページ数 | 5 |
| ジャーナル | Biological and Pharmaceutical Bulletin |
| 巻 | 34 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | 出版済み - 8 1 2011 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
これを引用
Werner interacting protein 1 promotes binding of werner protein to template-primer DNA. / Kanamori, Makoto; Seki, Masayuki; Yoshimura, Akari; Tsurimoto, Toshiki; Tada, Shusuke; Enomoto, Takemi.
：: Biological and Pharmaceutical Bulletin, 巻 34, 番号 8, 01.08.2011, p. 1314-1318.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Werner interacting protein 1 promotes binding of werner protein to template-primer DNA
AU - Kanamori, Makoto
AU - Seki, Masayuki
AU - Yoshimura, Akari
AU - Tsurimoto, Toshiki
AU - Tada, Shusuke
AU - Enomoto, Takemi
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.
AB - Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=80051538702&partnerID=8YFLogxK
U2 - 10.1248/bpb.34.1314
DO - 10.1248/bpb.34.1314
M3 - Article
VL - 34
SP - 1314
EP - 1318
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 8
ER -