Werner interacting protein 1 promotes binding of werner protein to template-primer DNA

Makoto Kanamori, Masayuki Seki, Akari Yoshimura, Toshiki Tsurimoto, Shusuke Tada, Takemi Enomoto

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.

本文言語英語
ページ(範囲)1314-1318
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
34
8
DOI
出版ステータス出版済み - 8月 2011

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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