White poplar: Targeted isolation of pancreatic lipase inhibitors

Marwa Elsbaey, Yhiya Amen, Toshinori Nakagawa, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

In order to discover new anti-obesity agents, twenty two natural extracts from medicinal plants and agricultural wastes were screened by pancreatic lipase inhibition assay. The methanolic extract of poplar wood (Populus alba L.), an important raw material for paper industry, showed promising inhibitory activity, its IC50 value was 7.15 μg/mL. Through bio-guided fractionation, the ethyl acetate fraction (E) was found to be the major contributor to the activity, IC50 = 4.7 μg/mL. Hence, it was subjected to bio-guided isolation and nine compounds (1–9) were identified from the active sub-fractions. The isolates were identified by means of one- and two-dimensional nuclear magnetic spectroscopy (1D, 2D-NMR), as well as high-performance liquid chromatography quadrupole time-of flight mass spectrometry (HPLC-QTOF-MS). (+)-Taxifolin (5) and (+)-ampelopsin (4) showed the highest activity, their IC50 values were 23.2 and 46.2 μM, respectively. The results indicated that flavonoids and phenolic acids in poplar wood could serve as potential candidates for development of new anti-obesity agents.

本文言語英語
論文番号111778
ジャーナルIndustrial Crops and Products
141
DOI
出版ステータス出版済み - 12 1 2019

All Science Journal Classification (ASJC) codes

  • 農業および作物学

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