Wnt signaling and glucocorticoid-induced osteoporosis

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

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Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Analyses of the mutations in LDL receptor-related protein 5 (LRP5), a Wnt co-receptor, revealed that the Wnt signaling pathway is important for bone formation. Glucocorticoids suppress the canonical Wnt signaling pathway by such mechanisms as the enhancement the expression of dickkopf-1 (Dkk-1) and secreted frizzled-related protein 1 (sFRP1), and activation of the glycogen synthase kinase-3beta (GSK-3beta) activity. The inhibition of the canonical Wnt signal by glucocorticoid may be involved in the pathogenesis of glucocorticoid-induced osteoporosis.

元の言語英語
ページ(範囲)1812-1816
ページ数5
ジャーナルClinical calcium
16
発行部数11
出版物ステータス出版済み - 1 1 2006

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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