抄録
Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Analyses of the mutations in LDL receptor-related protein 5 (LRP5), a Wnt co-receptor, revealed that the Wnt signaling pathway is important for bone formation. Glucocorticoids suppress the canonical Wnt signaling pathway by such mechanisms as the enhancement the expression of dickkopf-1 (Dkk-1) and secreted frizzled-related protein 1 (sFRP1), and activation of the glycogen synthase kinase-3beta (GSK-3beta) activity. The inhibition of the canonical Wnt signal by glucocorticoid may be involved in the pathogenesis of glucocorticoid-induced osteoporosis.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1812-1816 |
ページ数 | 5 |
ジャーナル | Clinical calcium |
巻 | 16 |
号 | 11 |
出版ステータス | 出版済み - 1月 1 2006 |
!!!All Science Journal Classification (ASJC) codes
- 医学(全般)