Wnt signaling and glucocorticoid-induced osteoporosis

研究成果: Contribution to journalReview article査読

5 被引用数 (Scopus)

抄録

Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Analyses of the mutations in LDL receptor-related protein 5 (LRP5), a Wnt co-receptor, revealed that the Wnt signaling pathway is important for bone formation. Glucocorticoids suppress the canonical Wnt signaling pathway by such mechanisms as the enhancement the expression of dickkopf-1 (Dkk-1) and secreted frizzled-related protein 1 (sFRP1), and activation of the glycogen synthase kinase-3beta (GSK-3beta) activity. The inhibition of the canonical Wnt signal by glucocorticoid may be involved in the pathogenesis of glucocorticoid-induced osteoporosis.

本文言語英語
ページ(範囲)1812-1816
ページ数5
ジャーナルClinical calcium
16
11
出版ステータス出版済み - 1 1 2006

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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