TY - JOUR
T1 - (–)-Xanthatin as a Killer of Human Breast Cancer MCF-7 Mammosphere Cells
T2 - A Comparative Study with Salinomycin
AU - Takeda, Shuso
AU - Hirao-Suzuki, Masayo
AU - Shindo, Mitsuru
AU - Aramaki, Hironori
N1 - Funding Information:
This work was performed under the Cooperative Research Program of the Network Joint Research Center for Materials and Devices (Research Nos. 20211327 and 20221077 (to S.T.) and 2012320, 2013373, 20163071 (to H.A.)). This work was supported by JSPS KAKENHI (17K08402 and 21K12261 (to S.T.), 22K15288 (to M.H.), and 22H02744 (to M.S.)). This study was also supported in part by the Research Foundation for Pharmaceutical Sciences (to M.H.), and the Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food industry (to M.S.).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed.
AB - Experimental evidence accumulated by our research group and others strongly suggests that (–)-xanthatin, a xanthanolide sesquiterpene lactone, exhibits anti-proliferative effects on human breast cancer cells (in vitro) as well as anti-tumor effects in experimental animals (in vivo). In cancer biology, it is now critically important for anti-cancer agents to selectively target cancer stem cells (CSCs) in order to overcome cancer therapeutic resistance and recurrence. However, it has not yet been established whether (–)-xanthatin abrogates the formation of breast CSCs. In the present study, we utilized chemically synthesized pure (–)-xanthatin and a culture system to obtain mammospheres from human breast cancer MCF-7 cells, which are a CSC-enriched population. We herein demonstrated for the first time that (–)-xanthatin exhibited the ability to kill mammospheres, similar to salinomycin, an established selective killer of CSCs. A possible anti-proliferative mechanism toward mammospheres by (–)-xanthatin is discussed.
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U2 - 10.3390/cimb44090264
DO - 10.3390/cimb44090264
M3 - Article
C2 - 36135176
AN - SCOPUS:85138295605
SN - 1467-3037
VL - 44
SP - 3849
EP - 3858
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
IS - 9
ER -
