Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer

Tomohiro Shibata, Eriko Tokunaga, Satoshi Hattori, Kosuke Watari, Yuichi Murakami, Nami Yamashita, Eiji Oki, Junji Itou, Masakazu Toi, Yoshihiko Maehara, Michihiko Kuwano, Mayumi Ono

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60% of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.

元の言語英語
ページ(範囲)37216-37228
ページ数13
ジャーナルOncotarget
9
発行部数98
出版物ステータス出版済み - 12 1 2018

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Carrier Proteins
Biomarkers
Breast Neoplasms
Genes
Databases
Gene Expression
Recurrence
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

これを引用

Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. / Shibata, Tomohiro; Tokunaga, Eriko; Hattori, Satoshi; Watari, Kosuke; Murakami, Yuichi; Yamashita, Nami; Oki, Eiji; Itou, Junji; Toi, Masakazu; Maehara, Yoshihiko; Kuwano, Michihiko; Ono, Mayumi.

:: Oncotarget, 巻 9, 番号 98, 01.12.2018, p. 37216-37228.

研究成果: ジャーナルへの寄稿記事

Shibata, T, Tokunaga, E, Hattori, S, Watari, K, Murakami, Y, Yamashita, N, Oki, E, Itou, J, Toi, M, Maehara, Y, Kuwano, M & Ono, M 2018, 'Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer', Oncotarget, 巻. 9, 番号 98, pp. 37216-37228.
Shibata, Tomohiro ; Tokunaga, Eriko ; Hattori, Satoshi ; Watari, Kosuke ; Murakami, Yuichi ; Yamashita, Nami ; Oki, Eiji ; Itou, Junji ; Toi, Masakazu ; Maehara, Yoshihiko ; Kuwano, Michihiko ; Ono, Mayumi. / Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. :: Oncotarget. 2018 ; 巻 9, 番号 98. pp. 37216-37228.
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abstract = "The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60{\%} of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.",
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