Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: Possible involvement of GABAA - Benzodiazepine receptor complex

Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABAA - benzodiazepine receptor complex, but not 5-HT1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.

本文言語英語
ページ(範囲)316-320
ページ数5
ジャーナルJournal of Pharmacological Sciences
116
3
DOI
出版ステータス出版済み - 2011

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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