ZGLP1 is a determinant for the oogenic fate in mice

So I. Nagaoka, Fumio Nakaki, Hidetaka Miyauchi, Yoshiaki Nosaka, Hiroshi Ohta, Yukihiro Yabuta, Kazuki Kurimoto, Katsuhiko Hayashi, Tomonori Nakamura, Takuya Yamamoto, Mitinori Saitou

研究成果: Contribution to journalArticle

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Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.

元の言語英語
ジャーナルScience (New York, N.Y.)
367
発行部数6482
DOI
出版物ステータス出版済み - 3 6 2020
外部発表Yes

All Science Journal Classification (ASJC) codes

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    Nagaoka, S. I., Nakaki, F., Miyauchi, H., Nosaka, Y., Ohta, H., Yabuta, Y., Kurimoto, K., Hayashi, K., Nakamura, T., Yamamoto, T., & Saitou, M. (2020). ZGLP1 is a determinant for the oogenic fate in mice. Science (New York, N.Y.), 367(6482). https://doi.org/10.1126/science.aaw4115